منابع مشابه
Tau Structures
Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger polymers in physiological and pathological situat...
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Starting from a so-called flat exact semisimple bihamiltonian structures of hydrodynamic type, we arrive at a Frobenius manifold structure and a tau structure for the associated principal hierarchy. We then classify the deformations of the principal hierarchy which possess tau structures. Mathematics Subject Classification (2010). Primary 37K10; Secondary 53D45.
متن کاملSubmajorization inequalities associated with $tau$-measurable operators
The aim of this note is to study the submajorization inequalities for $tau$-measurable operators in a semi-finite von Neumann algebra on a Hilbert space with a normal faithful semi-finite trace $tau$. The submajorization inequalities generalize some results due to Zhang, Furuichi and Lin, etc..
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Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...
متن کاملTau protein and tau aggregation inhibitors.
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly. The inhibitors can be clustered in several compound c...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2016
ISSN: 1663-4365
DOI: 10.3389/fnagi.2016.00262